Transcription of Introduction to Pharmacodynamics
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Introduction to Pharmacodynamics
CHAPTER. Introduction to Pharmacodynamics Reza Karimi 6. 1. Understand the physiology behind the gastrointestinal tract and the route of oral drug administration and Objectives physiological influences on Pharmacodynamics . 2. Understand the dynamics and functions of the major signal transduction systems and their different biomedi- cal and biological responses in regard to receptor ligand interactions. 3. Learn about the dynamics and mathematical expressions behind receptor ligand interactions. 4. Understand dose response relationships and factors that affect a pharmacological response. 5. Learn about agonistic, antagonistic, and partial agonistic binding of drugs to receptors.
5. First-pass metabolism: a type of metabolism in which drugs that are absorbed by the gastrointestinal tract go through the portal vein to the liver and are metabolized there before they are distributed to the general circulation. 6. Homeostasis: a balanced physiological process that protects and maintains the integrity of the internal envi-
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