Transcription of Introduction to Pharmacokinetics and Pharmacodynamics
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Introduction to Pharmacokinetics and Pharmacodynamics
LESSON. 1. Introduction to Pharmacokinetics and Pharmacodynamics C OBJECTIVES. After completing Lesson 1, you should be able to: 1. De ne and differentiate between Pharmacokinetics 5. Describe situations in which routine clinical phar- and clinical Pharmacokinetics . macokinetic monitoring would be advantageous. 2. De ne Pharmacodynamics and relate it to pharma- 6. List the assumptions made about drug distribution cokinetics. patterns in both one- and two-compartment models. 3. Describe the concept of the therapeutic concentra- 7.
Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabo-lism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient. Primary goals of clinical pharmacokinetics include
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