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Introduction to Quantitative Genomics / Genetics
OverviewHistory and IntuitionStatistical FrameworkApproachesChallengesIntroductio n to Quantitative Genomics / GeneticsBTRY 7210: Topics in Quantitative Genomics and GeneticsSeptember 10, 2008 Jason G. MezeyOverviewHistory and IntuitionStatistical FrameworkApproachesChallengesOutline History and Intuition. Statistical Framework. Current Approaches. Current and IntuitionStatistical FrameworkApproachesChallengesHistory Quantitative Genomcs / Geneticsmay be loosely definedas the field concerned with the statistical modeling of thegenetics of complex phenotypes. Relevant history: 1900-1980: statistical analysis of the patterns of inheritence( the resemblance between relatives). 1980-2002: mapping (= identification) of the genetic lociresponsible for most Mendelian diseases ( diseases wherealleles at a single genetic locus determines disease). 2002-present: age of Genomics first convincing mapping ofgenetic loci for complex traits ( cases where genotypecannot be inferred directly from the phenotype).
Overview History and Intuition Statistical Framework Approaches Challenges Introduction to Quantitative Genomics / Genetics BTRY 7210: Topics in Quantitative Genomics and Genetics
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