Transcription of Ionic Interaction to Achieve 24 Hour Zero Order …
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Ionic Interaction to Achieve 24 Hour Zero Order …
Ionic Interaction to Achieve 24 Hour Zero Order Release for a Freely Soluble Drug F. Cai, S. Yang, J. Cai, K. Zhang, H. Chen, R. Luo, M. Wang, X. Guo Prinston Pharmaceutical Inc., 2002 Eastpark Blvd, Cranbury, New Jersey 08512, USA Materials Objectives Background Methods Conclusions References AS, et al. J. Pharm. Sci., 93(2004):2319-31 S, Farmaco, 58(2003):1051-1056 S, et al. Eur. J. Pharm. Biopharm., 52(2001):75-82. SA, Drug Dev. Ind. Pharm., 27(2001):925-34. The extended-release (ER) products of highly water soluble drugs are commonly formulated as osmotic pump, bilayer/trilayer tablets, multi-pulse microparticles, matrix tablet with functional coating or matrix tablets using gastric retention technology. It is difficult to Achieve up to 24 hour release for matrix tablets composed of common release controlling non- Ionic polymers.
Ionic Interaction to Achieve 24 Hour Zero Order Release for a Freely Soluble Drug F. Cai, S. Yang, J. Cai, K. Zhang, H. Chen, R. Luo, M. Wang, X. Guo
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