Transcription of 간성 뇌증 - kasl.org
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간성 뇌증 - kasl.org
103PG 4PG Course 2012 Portal Hypertension Hepatic EncephalopathyHyung Joon KimDepartment of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, KoreaHepatic encephalopathy is one of the most important clinical manifestations in decompensated liver cirrhosis. Clinical manifestations are multiple and varied, ranging from minimal neurological changes to coma. Ammonia is the main toxic substance involved in the pathogenesis of hepatic encephalopathy, although other mechanisms, such as modifications of the blood-brain barrier, disruptions in neurotransmission and abnormalities in GABA ergic and benzodiazepine pathways may also play a role. The identification and treatment of precipitating factors is crucial in the management of patients with hepatic encephalopathy. Current treatments are based on reducing intestinal ammonia load by agents such as antibiotics or disaccharides, although their efficacy is yet.
김형준 간성 뇌증 105 서 문맥 혈류가 바로 체순환으로 유입이 되고, 또한 손상된 간기능에 의해서 암모니아의 해독작용이 감소
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