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La terapia delle infezioni da S. aureo “difficile”

La terapia delle infezioni da S. aureo difficile Prof. Ercole ConciaUniversit degli studi di VeronaVerona, 22 ottobre 2010 EVOLUTION OF RESISTANCE IN S. AUREUS1940:Benzylpenicillin (penG) introduced1948: -lactamase-positive strains predominate1950s:Resistant to all available agents1960s:Semi-synthetic penicillins introduced1961:Methicillin-resistant strains appeared1970s:Multidrug-resistant (MDR) MRSA strains detected1980s:Global spread of MDR MRSA1990s:Increasing MRSA in hospitals, sporadic nosohusial cases1997:VISA and hVISA( reduced vancomycin susceptibility)1998:CA-MRSA no link to healthcare institutions 2002:VRSA (VanA)MRSA Rates are Increasing worldwideGrundmann H, et al. Lancet2006; 368:874 8501020304050607080901001999200020012002 20032004200520062007 Rate of invasive MRSA in Italy: 1999-2007 MRSA in Ospedale EARSS 2004020406080 ICUO ncologyUrologyPaediatricsObstetricsOrtho pedicsNeurosurgeryInternal in different clinical settingsMSSA (363)MRSA (199) OASIS Staphylococcus aureus: resistenze associate a MSSA e MRSAG.

La terapia delle infezioni da S. aureo “difficile” Prof. Ercole Concia Università degli studi di Verona Verona, 22 ottobre 2010

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