Transcription of Loop Diuretics for Patients With Acute Renal Failure
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Loop Diuretics for Patients With Acute Renal Failure
EDITORIALS Editorials represent the opinions of the authors and THE JOURNAL and not those of the American Medical Association. Loop Diuretics for Patients with Acute Renal Failure Helpful or Harmful? Norbert Lameire, MD, PhD acidemic complications; requires less dialysis; and has a lower mortality ,10 However, the distinction between oli- Raymond Vanholder, MD, PhD guric and nonoliguric Acute tubular necrosis is somewhat Wim Van Biesen, MD, PhD arbitrary, because urine flow rates in Patients with Acute tu- bular necrosis represent a continuum from very low to high I. NTRINSIC Acute Renal Failure (ARF) THAT DOES NOT. values without an obvious biphasic distribution. Most prob- result from primary vascular, glomerular, or intersti- ably, the residual level of glomerular filtration rate is the tial disorders has been ascribed to Acute tubular necro- primary determinant of variations in urine flow rate in sis and accounts for approximately 45% of cases of hos- Patients with pital-acquired While Acute tubular necrosis usually Several theoretical arguments support the use of manni- is caused by ischemic (50%) or nephrotoxic (35%) injury tol and loop Diuretics for prevention or treatment
EDITORIALS Editorials represent the opinions of the authors and THE JOURNAL and not those of the American Medical Association. Loop Diuretics for Patients With Acute Renal Failure Helpful or Harmful? Norbert Lameire, MD, PhD
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