Transcription of LOSS OF DNA MISMATCH REPAIR PROTEIN …
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LOSS OF DNA MISMATCH REPAIR PROTEIN …
Int J Clin Exp Pathol (2008) 1, 502-509 Original Article Loss of DNA MISMATCH REPAIR PROTEIN hMSH6 in Ovarian Cancer is Histotype-Specific Qihui Jim Zhai1, Daniel Gustavo Rosen2, Karen Lu3 and Jinsong Liu2 1 Department of Pathology, The Methodist Hospital, Houston Texas; Departments of 2 Pathology and 3 Gynecology Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas Received 27 December 2007; Accepted with revision 14 January 2008; Available online 31 January 2008 Abstract: Microsatellite instability (MSI) due to defects in DNA MISMATCH REPAIR genes may be involved in the development of a subset of human ovarian carcinomas.
Zhai et al/hMSH6 in Ovarian Cancer colorectal cancer came from the description of such mutations in two cell lines, HCT-15 and MT1, derived from tumors displaying MSI, primarily as mononucleotide repeats [7].
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