Transcription of Masterpieces in Process Chemistry
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Masterpieces in Process ChemistryRichter11/3/04 Group MeetingSelected Syntheses Discussed:OOMeOHMeHOMeOHMeMeMeOHMeOMeHON H2 DiscodermolideNovartisEGFR Irreversible InhibitorPfizerNNHNHNOONOFClNCO2 HOHK etorolacSyntexOSONHOOHERa-SERMM erckSNHHNOCO2 HHHHB iotinTanabe Seiyaku H3PO4 TamifluHoffmann-LaRocheFMeOOHNHNHONCNMIV -105 ChironNHSMeHNOOMeNAmergeGlaxoSmithKlineN ClNOOMeNClNHClaritinSchering-PloughClari nexSchering-PloughNOMeHNNCF3 OCO2 HHSB-273005 GlaxoSmithKlineMasterpieces in Process ChemistryRichter11/3/04 Group MeetingSelected Syntheses Not Discussed:Ecteinascidin 743 CoreyNMeNNHSOHHHOHHHOMeOOAcOMeOOHOOMeMeN NOONCO2 MeCO2 MeClOCF3 IndoxacarbDuPontNOHMeOHCO2 NH3+HThienamycinMerckSee Jeremy richter , Baran Group Meeting, January 2004 NMeOClOHHONMeNFTI CandidatePfizerF3 CONHMeProzacEli LillyNHNSNNMeMeZyprexaEli LillyOOOOOOOOOOOOOOOOHMeMeHHHHMeMeHOHOHO HHHHHHHHHHHHHHHHHH alichondrinKishiDisclaimers:1.
Richter Masterpieces in Process Chemistry11/3/04 Group Meeting O O Me OH Me HO Me OH Me Me Me OH Me O Me H O NH2 (–)-Discodermolide 1. Non-taxane microtubule stabilizing agent (most potent known). 2. Small amounts available naturally and must be harvested by manned
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