Transcription of Mediation and interaction analysis Introduction and ...
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Mediation and interaction analysisIntroduction and overview of Stata commandsAndrea BellaviaUtrecht Exposome Hub, Utrecht UniversityDepartments of Environmental Health, Harvard Chan School of Public Stata Biostatistics and Epidemiology Virtual Symposium@andreabellaviaMediation analysisFebruary 18, 20211 / 22 Outline1. Principles of Mediation and pathway analysis2. Overview of current approaches and STATA Classical (Baron & Kenny) Structural Equation Modeling Counterfactual approach to Mediation General approach (Imai)3. Extensions and current gaps4. Themed4waycommand (Rino Bellocco)@andreabellaviaMediation analysisFebruary 18, 20212 / 221. Principles of Mediation and pathway analysisMediation and pathway analysis attempts to elucidate the mechanismsunderlaying an observedX is the association generated?Does the association only exist for specific subgroups? Mediation and pathway analysis address the how question. Interactionanalysis addressed the for whom question@andreabellaviaMediation analysisFebruary 18, 20213 / 22 Mediation analysis - formal definitionA mediator is a covariate that mediates the association between X and of the effect of X on Y is due to the fact that X causes M, which inturn causes Y@andreabellaviaMediation analysisFebruary 18, 20214 / 22We aim to disentangle the total effect of X on Y into a direct effect thatgoes through all possible pathways but M.
High-dimensional mediation analysis (Blum et al. 2020) Time-varying exposures, mediators, and confounders (VanderWeele et al. (2017) Sensitivity analyses for the counterfactual approach (Vanderweele 2010) Multiple imputations @andreabellavia Mediation analysis February 18, 2021 21 …
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