Transcription of Medical Statistics: Clinical Trials
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Medical Statistics: Clinical Trials
Medical statistics : Clinical Trials Nick Fieller Clinical Trials ; Contents NRJF, 1996 i Contents 0. Introduction .. 1 Books .. 1 Objectives .. 2 Organization of course material .. 3 A Note on R, S-PLUS and MINITAB .. 4 Data sets .. 5 R data sets .. 5 Data sets in other formats .. 6 R libraries required .. 6 Outline of Course .. 7 1. Background and Basic Concepts .. 9 Definition of Clinical Trial (from Pocock, 1983) .. 9 Historical Background .. 10 Field Trial of Salk Polio Vaccine .. 11 Types of Trial .. 14 Further notes: .. 15 Placebo Effect .. 18 Nocebo Effect .. 18 Blindness of Trials .. 18 Ethical Considerations .. 19 Publication Ethics .. 21 Evidence-Based Medicine .. 22 The Bradford-Hill Criteria .. 22 Summary & Conclusions .. 24 Tasks 1 .. 25 2. Basic Trial 27 Comments on Tests .. 27 One-sided and two-sided tests .. 27 Separate and Pooled Variance t-tests.
Clinical Trials; Introduction © NRJF, 1996 1 Statistical Methods in Clinical Trials 0. Introduction 0.1 Books Altman, D.G. (1991) Practical Statistics for Medical ...
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