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International Journal of PharmTech ResearchCODEN (USA): IJPRIF ISSN : , , pp1750-1757, Oct-Dec2012 Method Development And Validation Of ForcedDegradation Studies Of Pioglitazone HydrochlorideBy Using UV SpectroscopyNarsimha rao. Doredla*, ,Raju. Bojjagani, Syam vardhan. MadasuDepartment of Pharmaceutical Analysis Sarada College of PharmaceuticalSciences, Kondakavuru, Narasaraopet, Guntur No: +91-9985361467 Abstract:Pioglitazone hydrochloride is an oral antidiabetic agent used in the treatment of type 2 diabetesmellitus and also known as non-insulin dependent diabetes mellitus (NIDDM) or adult onset , an accurate and economic, precise and reproducible UV Spectroscopy Method has been developedfor the estimation ofPioglitazone hydrochloride tabletdosage form and validated by ICH guidelines. Thestandard (10 g/ml) was scanned between 200-400 nm and maximumabsorption was recorded at 270 assay results are found to be The linearity range of 10-50 g/ml proved that it obeyedBeer s Law and the correlation coefficient (r2) was found to be at 270 nm with an intercept a slope of with RSD complied pH degradation studies of tablet formulationwere found to be less at pH 6-8.
Narsimha rao. Doredla et al /Int.J.PharmTech Res.2012,4(4) 1751 Determination of pioglitazone by various analytical methods like Spectrophotometric method(2 ) and HPLC and MECK method(3 ) in
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