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METHOTREXATE CLINICAL PRACTICE GUIDELINES FOR …

Mary Pack Arthritis Program METHOTREXATE CLINICAL PRACTICE GUIDELINES FOR STAFF TITLE: Handling of premixed injectable METHOTREXATE (MTX) by employees who are pregnant, breast-feeding or attempting to reproduce Date: July 1997 Reviewed: January 2009 PURPOSE: To outline policy, GUIDELINES and procedures that protect nurses, physicians and caregivers from health risks associated with preparation, administration and disposal of MTX. POLICY: 1. Employees who are pregnant, breast-feeding or trying to reproduce will follow procedures for safe handling standards for cytotoxic agents as outlined in Cytotoxic Standards (2008). 2. It is the responsibility of the employees handling MTX to discuss with their department supervisor any desired change in work assignment as a result of pregnancy, breast feeding or trying to reproduce. RATIONALE: An extensive review of the scientific literature indicates that MTX has the potential to be teratogenic.

2. Employees will use the Cytotoxic Standards (2008); Clinical Practice Guidelines and references to enable them to make informed decisions regarding handling of MTX. The references will be updated annually and/or revised as new evidence and expert opinion

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