Transcription of MGL-3196, a selective thyroid hormone receptor …
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1 MGL-3196, a selective thyroid hormone receptor -beta agonist, significantly decreases hepatic fat in NASH patients at 12 weeks, the primary endpoint in a 36 week serial liver biopsy studyStephen Harrison1, Sam Moussa2, Mustafa Bashir3, NaimAlkhouri4, Juan Frias5, Seth Baum6, Brent Tetri7, MeenaBansal8, Rebecca Taub9; 1 Oxford University ; 2 University of Arizona for Medical Sciences ; 3 Duke University Medical Center ; 4 Texa s L i v e r I n s t i t u t e , S a n A n t o n i o , T X ; 5 University of California San Diego, Endocrinology, San Diego, United States ; 6 Florida Atlantic University ; 7St Louis University School of Medicine ; 8 Icahn School of Medicine at Mount Sinai ; 9 Madrigal PharmaceuticalsMechanism of Action: The Importance of Liver THR- in NASH2 thyroid Gland Liver T4 T3 T4 T3 Nuc thyroid hormone receptor or TSH thyroid hormone Pathway T4 T4, prohormone T3, ac/ve hormone TSH, thyroid s/mula/ng hormo
1 MGL-3196, a selective thyroid hormone receptor-beta agonist, significantly decreases hepatic fat in NASH patients at 12 weeks, the primary …
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