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MITOCHONDRIA, THEIR STRUCTURE, FUNCTIONS, AND …

MITOCHONDRIA, THEIR STRUCTURE, FUNCTIONS, AND. DISEASES LINKED TO THE ORGANELLE. Introduction. Part structure of mitochondria. A). Morphology and organelle interactions. B). The fusion fission cycle of mitochondria. C). Internal structure. D). MtDNA, structure and packaging. E). Import of proteins into mitochondria. Part 2. Mitochondrial functioning in intermediary metabolism. A). Post-translational modifications control of Mitochondrial metabolism. B). Pyruvate dehydrogenase. C). Succinate dehydrogenase. D). The ATP synthase. Part 3. Mitochondria in apoptosis. Part 4. Control of mitochondrial levels: production versus destruction. A). Biogenesis. B). Mitophagy. Part 5. Mitochondria in disease. A) Oxidative phosphorylation deficiencies. B). Fatty acid oxidation disorders. C). Mitochondria in the innate immune response. D). Mitochondria and cancer. E). Mitochondria and neurodegeneration. Parkinsons disease, Alzheimers disease, ALS, Huntingtons disease).

Alzheimers disease, ALS, Huntingtons disease). INTRODUCTION Mitochondria are now known to be more than the hub of energy metabolism. They are the central executioner of cells, and control cellular homeostasis through involvement in nearly all aspects of metabolism. As our understanding of mitochondria has expanded it

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