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Published OnlineFirst June 26, 2015; DOI: Molecular Pathways Clinical Cancer Research Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47. "Don't Eat Me" Signals Melissa N. McCracken1,2,3, Adriel C. Cha1,2,3,4, and Irving L. Weissman1,2,3,5. Abstract Recent advances with immunotherapy agents for the treat- innate Cells are also professional antigen-presenting Cells ment of Cancer have provided remarkable, and in some cases, (APC), providing a link from innate to adaptive antitumor curative results. Our laboratory has identi ed CD47 as an immunity. Preliminary studies have demonstrated that APCs important "don't eat me" signal expressed on malignant Cells .
Molecular Pathways Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals Melissa N. McCracken1,2,3, Adriel C. Cha1,2,3,4, and Irving L.Weissman1,2,3,5 Abstract
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