Transcription of NAFLD/NASHの最近の動向 - NCGM
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NAFLD/NASHの最近の動向 - NCGM
NAFLD/NASH 2020 1 24 2 Syndrome X Deadly quartet 1988 Reaven 1989 Kaplan 1991 DeFronzo 1987 (Matsuzawa) (WHO, 1998) NCEP-ATPIII 2001 1. 102 cm 88 cm 2. 150 mg/dL 3. HDL- 40 mg/dL 50 mg/dL 4. 130/85 mmHg 5. 110 mg/dL 85cm 90cm 150mg/dL 40mg/dL 130mmHg 85mmHg 110mg/dL ( ) HDL( ) 94 (4) : 794-809, 2005 1. A, B, C) 2. B, C) 3. B, C) 4. B, C) 5. 6. - - - - CoA TCA GLUT2 GK G-6-Pase GS PLa Phospho- glucomutase FFA FFA CD36 FFA influx TG VLDL MTTP TG excretion Acyl-CoA ACOX1 -oxidation SREBP-1c lipogenesis Acetyl-CoA Fatty acid Synthase PPAR , 2007; 104: 492-500 24
(Yoneda M, et al. GUT 56: 13301331, 2007-) 報告 年代 症例 年齢 BMI 線維化 AUROC ...
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