Transcription of Natural products to drugs: natural product derived ...
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Natural products to drugs: natural product derived ...
REVIEW. Natural products to drugs: Natural product derived compounds in clinical trials NPR. Mark S. Butler*. MerLion Pharmaceuticals, 1 Science Park Road, The Capricorn #05-01, Singapore Science Park II, Singapore 117528. E-mail: Fax: +65 6829 5601;. Tel: +65 6829 5611. Received (in Cambridge, UK) 13th January 2005. First published as an Advance Article on the web 8th March 2005. Covering: 31st December 2004. Natural product and Natural product - derived compounds that are being evaluated in clinical trials or in registration (current 31 December 2004) have been reviewed. Natural product derived drugs launched in the United States of America, Europe and Japan since 1998 and new Natural product templates discovered since 1990 are discussed. 1 Introduction 1 Introduction 2 NP derived drugs launched since 1998.
Table 1 NP-derived drugs launched in the United States, Europe or Japan since 1998 by year with reference to their lead compound, classification and therapeutic area Year Generic name (trade name) Lead compound Classification Disease area References 1998 orlistat (XenicalR) lipstatin semi-synthetic NPa antiobesity 35–39 1998 cefoselis (WincefR) cephalosporin NP-deriveda antibacterial …
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