Transcription of NCCN Guidelines Version 1.2016 NCCN Guidelines …
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NCCN Guidelines Version 1.2016 NCCN Guidelines …
nccn Guidelines Version nccn Guidelines Index NHL Table of Contents Mycosis Fungoides/Sezary Syndrome Discussion DIAGNOSIS. ESSENTIAL: Biopsy of suspicious skin sites Multiple biopsies may be necessary to capture the pathologic variability of disease at diagnosis Dermatopathology review of slidesa USEFUL UNDER CERTAIN CIRCUMSTANCES: IHC panel of skin biopsyb,c,d CD2, CD3, CD4, CD5, CD7, CD8, CD20, CD30, CD25, CD56, TIA1, granzyme B, F1, TCR-C M1. Molecular analysis of skin biopsy: TCR gene Workup (MFSS-2). rearrangements (assessment of clonality)b by PCR. methodse Assessment of peripheral blood for Sezary cells (in cases where skin is not diagnostic, especially T4) including: Sezary cell prep Flow cytometry (CD3, CD4, CD7, CD8, CD26 to assess for expanded CD4+ cells with increased CD4/CD8 ratio or with abnormal immunophenotype, including loss of CD7 or CD26) and PCR for TCR gene rearrangement Bio
NCCN Guidelines Index NHL Table of Contents Discussion Version 1.2016, 11/24/15 © National Comprehensive Cancer Network, Inc. 2015, All rights reserved.
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