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New ESPGHAN guidelines for the diagnosis of …
New ESPGHAN guidelines for the diagnosis of Coeliac disease in children and AdolescentsSteffen HusbyHans Christian Andersen children s Hospital Odense University Hospital, DenmarkAgenda Change in clinical paradigm Definitions of coeliac disease New diagnostic guidelines Algorithms Interlaken ESPGHAN criteria (1979) intestinal biopsy: villous atrophy free diet for 1-2 : normal. of gluten : villous atrophy McNeish et al. Arch Dis Childh 1979;54:783 Revised ESPGHAN criteria intestinal biopsy: villous and serological improvement after 2-3 months No further biopsy Provided age > 2 yearsWalker Smith et al. Arch Dis Child 1990;65:99 General:Puberty & growth delayMalignanciesAnemiaGI system:Diarrhea, vomitingDistension, painMalnutrition, weight lossHepatitis, cholangitisBone:Osteoporosis, fracturesArthritisDental anomaliesCNS:Ataxia, seizuresDepressionHeart:CarditisSkin & mucosa:Dermatitis herpetiformisAphtous stomatitisHair lossReproductive system:MiscarriageInfertilityModified fromRewers, Gastroenterology 2005 Celiac disease as a multiorgan autoimmune diseaseCoeliac diseaseType 1 DiabetesDermatitis herpetiformisAutoimmune hypothyroidismAdrenal antibodiesHansen et al.
New ESPGHAN guidelines for the diagnosis of Coeliac Disease in Children and Adolescents Steffen Husby Hans Christian Andersen Children’s Hospital
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