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New response evaluation criteria in solid tumours: Revised ...

New response evaluation criteria in solid tumours: Revised RECIST guideline (version ) Eisenhauera,*, P. Therasseb, J. Bogaertsc, Schwartzd, D. Sargente, R. Fordf,J. Danceyg, S. Arbuckh, S. Gwytheri, M. Mooneyg, L. Rubinsteing, L. Shankarg, L. Doddg,R. Kaplanj, D. Lacombec, J. VerweijkaNational Cancer Institute of Canada Clinical Trials Group, 10 Stuart Street, Queen s University, Kingston, ON, CanadabGlaxoSmithKline Biologicals, Rixensart, BelgiumcEuropean Organisation for Research and Treatment of Cancer, Data Centre, Brussels, BelgiumdMemorial Sloan Kettering Cancer Center, New York, NY, USAeMayo Clinic, Rochester, MN, USAfRadPharm, Princeton, NJ, USAgDivision of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USAhSchering-Plough, Kenilworth, NJ, USAiEast Surrey Hospital, Redhill, Surrey, UKjNational Cancer Research Network, Leeds, UKkErasmus University Medical Center, Rotterdam, The NetherlandsARTICLE INFOA rticle history:Received 17 October 2008 Accepted 29 October 2008 Keywords: response criteriaSolid tumoursGuidelinesABSTRACTB ackground:Assessment of the change in tumour burden is an important feature of theclinical evaluation of cancer therapeutics.

dence of anti-tumour effect is supported by years of evi-dence suggesting that, for many solid tumours, agents which produce tumour shrinkage in a proportion of patients have a reasonable (albeit imperfect) chance of subsequently demonstrating an …

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