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Next-Generation DNA Sequencing Methods

ANRV353-GG09-20 ARI25 July 200814:57 Next-Generation DNAS equencing MethodsElaine R. MardisDepartments of Genetics and Molecular Microbiology and Genome Sequencing Center,Washington University School of Medicine, St. Louis MO 63108; email: Rev. Genomics Hum. Genet. :387 402 First published online as a Review in Advance onJune 24, 2008 TheAnnual Review of Genomics and Human Geneticsis online at article s 2008 by Annual rights reserved1527-8204/08/0922-0387$ Wordsmassively parallel Sequencing , Sequencing -by-synthesis, resequencingAbstractRecent scientific discoveries that resulted from the application of Next-Generation DNA Sequencing technologies highlight the striking impactof these massively parallel platforms on genetics.

next-generation platforms are helping to open entirely new areas of biological inquiry, includ-ing the investigation of ancient genomes, the characterization of ecological diversity, and the identification of unknown etiologic agents. NEXT-GENERATION DNA SEQUENCING Three platforms for massively parallel DNA sequencing read production are in ...

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