Transcription of リスク評価における不確実係数の表現法 - NIHS
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リスク評価における不確実係数の表現法 - NIHS
Hazard Identification Dose-response Assessment Exposure Assessment Risk Characterization 2 Problem Formulation Toxic effects with threshold Toxic response Dose 0 Threshold Toxic response Dose 0 Non-threshold carcinogenicity (DNA-direct acting chemicals) TDI/ADI approach (UF approach) Linear extrapolation or MOE approach (BMD method) 3 ( ) (UF) [ (SF) ] 100 ( ) 100 (100) 100 1mg 50kg 2 mg/kg/ 1/100 mg/kg/ 1mg 4
ADI: Acceptable Daily Intake ） 又は耐容一日摂取量（ TDI: Tolerable Daily Intake ）の算定。 ADI = NOAEL/SF (Safety factor: 安全係数) TDI = NOAEL/UF (Uncertainty factor : 不確実係数) 不確実性の要因
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