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核酸医薬開発の動向と課題 - nihs.go.jp

2013 12 13 ! ! 5 ! NIHS Since 1874 NIHS Since 1874 ! !1 2 3 = Oligonucleotide Therapeutics! * * ! ! !!! ! ! ! ! mRNA! Promoter!Gene!RISC ! 1 DNA/RNA 2 DNA siRNA! 2 RNA ! miRNA!miRNA miRNA mimic! 2 RNA ! ! DNA! ! 1 DNA/RNA Non-coding !miRNA CpG !CpG 1 DNA! ! 1 DNA/RNA ! !promoter! !

核酸医薬品とは 核酸医薬品 = Oligonucleotide Therapeutics! ・ ヌクレオチド*を基本骨格とする(*天然型または化学修飾型)! ・ 遺伝子発現を介さずに直接生体に作用する! ・ 化学合成により製造!

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