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NSAIDS - DARE TO COMPARE - RxFiles

NSAIDsDARE TO COMPARETheRxFilesTheRxFilesTheRxFilesThe RxFilesJuly 1997 vProduced by the Community Drug Utilization Program,a Saskatoon District Health/St. Paul's Hospital programfunded by Saskatchewan Health. For more information checkour website or, contact Loren Regier C/O Pharmacy Department, Saskatoon City Hospital, 701 Queen St. Saskatoon, SK S7K 0M7, Ph (306)655-8506,Fax (306)655-8804; Email have come a long way from the days of willowbark. Today salicylates and non-steroidal anti-inflammatory drugs ( NSAIDS ) comprise one of thelargest and most commonly prescribed groups ofdrugs In Saskatchewan, over 20different agents are available, accounting for morethan 300,000 prescriptions and over $7 million insales each year (Saskatchewan Health-Drug Plandata 1996). Despite the wide selection, NSAID sare more alike than different. Although they dodiffer in chemical structure, pharmacokinetics, andto some degree pharmacodynamics, they sharesimilar mechanisms of action, efficacy, and work by inhibiting cyclooxygenase (COX)and subsequent prostaglandin synthesis as well asby other less understood mechanisms.

NSAIDs DARE TO COMPARE TheRxFiles July 1997 v Produced by the Community Drug Utilization Program, a Saskatoon District Health/St. Paul's Hospital program funded by Saskatchewan Health. For more information check

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