Transcription of ORIGINAL ARTICLE FORMULATION AND IN VITRO RELEASE …
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ORIGINAL ARTICLE FORMULATION AND IN VITRO RELEASE …
FARMACIA, 2015, Vol. 63, 1 111 ORIGINAL ARTICLE FORMULATION AND IN VITRO RELEASE TESTING OF RECTAL SUPPOSITORIES CONTAINING NIMESULIDE ANCA CECILIA NICOAR 1, RADU GEORGE CAZACINCU2*, DUMITRU LUPULEASA1, DALIA SIMONA MIRON3, FLAVIAN TEFAN R DULESCU4 1 University of Medicine and Pharmacy Carol Davila Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 6 Traian Vuia street, 020956, Bucharest, Romania 2 Ovidius University, Faculty of Pharmacy, 1 Aleea Universitatii, Constanta, Romania 3 University of Medicine and Pharmacy Carol Davila Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Physics and Informatics. 6 Traian Vuia street,020956, Bucharest, Romania 4 University of Medicine and Pharmacy Carol Davila Bucharest, Faculty of Pharmacy, Department of Drug Industry and Pharmaceutical Biotechnologies, 6 Traian Vuia street, 020956, Bucharest, Romania *corresponding author: Manuscript received: November 2014 Abstract Rectal suppositories containi
FARMACIA, 2015, Vol. 63, 1 114 similarly to the disintegration tests performed on the oral solid dosage forms. The analysis of in vitro release profiles showed an extremely low nimesulide release.
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