Transcription of Overview of Upstream and Downstream Processing …
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Overview of Upstream and Downstream Processing …
Overview of Upstream and Downstream Processing of Biopharmaceuticals1 Ian MarisonProfessor of Bioprocess Engineering and Head of School of Biotechnology,Dublin City University, Glasnevin, Dublin 9, IrelandE-mail: of presentation Introduction- what is a bioprocess? Basis of process design Upstream Processing Batch, fed-batch, continuous, perfusion2 Batch, fed-batch, continuous, perfusion Downstream Processing Philosophy Chromatography Examples ConclusionsWhat is a bioprocess? Application of naturalor genetically manipulated(recombinant) whole cells/ tissues/ organs, or partsthereof, for the production of industrially or medically important products Examples3 Examples Agroalimentaire: food/ beverages Organic acids and alcohols Flavours and fragrances DN
Biomass-product separation Product purification Storage properties, stability Effluent recycle/disposal Concentration, crystallization, drying Fill-Finish
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