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Overview of Upstream and Downstream Processing …
Overview of Upstream and Downstream Processing of Biopharmaceuticals1 Ian MarisonProfessor of Bioprocess Engineering and Head of School of Biotechnology,Dublin City University, Glasnevin, Dublin 9, IrelandE-mail: of presentation Introduction- what is a bioprocess? Basis of process design Upstream Processing Batch, fed-batch, continuous, perfusion2 Batch, fed-batch, continuous, perfusion Downstream Processing Philosophy Chromatography Examples ConclusionsWhat is a bioprocess? Application of naturalor genetically manipulated(recombinant) whole cells/ tissues/ organs, or partsthereof, for the production of industrially or medically important products Examples3 Examples Agroalimentaire: food/ beverages Organic acids and alcohols Flavours and fragrances DNA for gene therapy and transient infection Antibiotics Proteins (mAbs, tPA, hirudin, Interleukins, Interferons, enzymes etc) Hormones (insulin, hGH,EPO,FSH etc)Aims of bioprocesses To apply and optimize natural or artificial biological systems by manipulation of cells and their environment to produce the desired product, of the required quality.
Biomass-product separation Product purification Storage properties, stability Effluent recycle/disposal Concentration, crystallization, drying Fill-Finish
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