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Oxygen Saturation: A Guide to Laboratory …

10 CLINICAL Laboratory NEWS FEBRUARY 2006 CLN SLAB 2006:SUPPORTING CLINICALDECISIONSSERIESThe Clinical Laboratory Standards In-stitute (CLSI) defines O2sat as an estimated value based on a calculation, whereas SaO2and SpO2 refer to the arterial saturation measured spectrophotometrically. (To avoid further confusion, I will use only O2sat and SO2 for the remainder of this article.) CO-oximetry, a more complex and reliable method, measures the concentration of he-moglobin derivatives in the blood, the results of which are then used to calculate various parameters such as hemoglobin derivative fractions ( , FO2Hb), total hemoglobin, and Oxygen most patients, the results O2sat, SO2, and FO2Hb from these three methods are virtually identical.

CLINICAL LABORATORY NEWS FEBRUARY 2006 11 lung alveoli. The same process works in re-verse in the tissues; once fully loaded …

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