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PARACETAMOL: MECHANISM OF ACTION, APPLICATIONS …

Acta Poloniae Pharmaceutica Drug Research, Vol. 71 No. 1 pp. 11 23, 2014 ISSN 0001-6837. Polish Pharmaceutical Society PARACETAMOL: MECHANISM OF ACTION, APPLICATIONS . AND SAFETY CONCERN. MARTA J WIAK-B BENISTA* and JERZY Z. NOWAK. Department of Pharmacology, Chair of Pharmacology and Clinical Pharmacology at the Medical University of d , eligowskiego 7/9, 90-752 d , Poland Abstract: Paracetamol / acetaminophen is one of the most popular and most commonly used analgesic and antipyretic drugs around the world, available without a prescription, both in mono- and multi-component prepa- rations. It is the drug of choice in patients that cannot be treated with non-steroidal anti-inflammatory drugs (NSAID), such as people with bronchial asthma, peptic ulcer disease, hemophilia, salicylate-sensitized people, children under 12 years of age, pregnant or breastfeeding women. It is recommended as a first-line treatment of pain associated with osteoarthritis.

lene (Fig. 1). They noticed that the drug had a small impact on intestinal parasites, however, it signifi-cantly decreased high temperature. Young doctors - Arnold Chan and Paul Heppa - quickly published their discovery and acetanilide was introduced into medical practice in 1886 under the name of antifebrin (1). Soon it appeared that although ...

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