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Parameter Estimation - ML vs. MAP

ParameterEstimationPeter NRobinsonEstimatingParametersfrom DataMaximumLikelihood(ML)EstimationBetad istributionMaximum aposteriori(MAP)EstimationMAQP arameter EstimationML vs. MAPP eter N RobinsonDecember 14, 2012 ParameterEstimationPeter NRobinsonEstimatingParametersfrom DataMaximumLikelihood(ML)EstimationBetad istributionMaximum aposteriori(MAP)EstimationMAQE stimating parameters from DataIn many situations in bioinformatics, we want to estimate op-timal parameters from data. In the examples we have seen inthe lectures on variant calling, these parameters might be theerror rate for reads, the proportion of a certain genotype, theproportion of nonreference bases etc.

Parameter Estimation Peter N Robinson Estimating Parameters from Data Maximum Likelihood (ML) Estimation Beta distribution Maximum a posteriori (MAP) Estimation MAQ Discrete Random Variable Let us begin to formalize this. We model the coin toss process as follows. The outcome of a single coin toss is a random variable X that can take on values ...

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