Transcription of Parathyroid hormone (serum, plasma)
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Parathyroid hormone (serum, plasma)
Copyright Association for Clinical Biochemistry 2012 1 Parathyroid hormone (serum, plasma) 1 Name and description of analyte Name of analyte Parathyroid hormone (PTH) Alternative names Parathormone NMLC code Description of analyte PTH is an 84 amino acid linear peptide hormone (MW ~9500 Da). It is synthesised as a larger precursor (115 amino acids); the removal of a chain of 25 amino acids produces pro PTH from which removal of a further six amino acids produces PTH. It is secreted exclusively by the Parathyroid glands. The principal stimulus to secretion is a low ionised [calcium], which is sensed by a calcium sensing receptor located on the plasma membrane of Parathyroid cells. Secretion is inhibited by an increased ionised [calcium]. Secretion is also reversibly inhibited by severe hypomagnesaemia. The parathyroids also secrete fragments of PTH, and hepatic and renal metabolism of the hormone also result in the appearance of fragments of PTH in plasma.
© Copyright Association for Clinical Biochemistry 2012 1 Parathyroid hormone (serum, plasma) 1 Name and description of analyte 1.1 Name of analyte Parathyroid ...
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