Transcription of Pathophysiology of Migraine
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Pathophysiology of Migraine
1 Pathophysiology of MigrainePathophysiology of Migraine2 Migraine Pathophysiology : A NEUROVASCULAR HEADACHEMIGRAINE Pathophysiology : A NEUROVASCULAR HEADACHER eview the neurobiology of Migraine - Features of acute attack- neuroanatomical substratesDiscuss the current understanding of Migraine , vulnerability, initiation and activation of the trigeminocervical pain systemObjectivesDescribe the modulation of head pain in the CNS 3 WHAT IS Migraine ?WHAT IS Migraine ?Neurobiologically based, common clinical syndrome characterized by recurrent episodic attacks of head pain which serve no protective purposeThe headache is accompanied by associated symptoms such as nausea, sensitivity to light, sound, or head movementThe vulnerability to Migraine if for many, an inherited tendencyMigraine is a complex neurobiological disorder
NcoI alleles. Neurology. 1997;49:201-206. 9 THE P/Q GENE PRODUCTTHE P/Q GENE PRODUCT Ophoff RA et al. Cell. 1996. This diagram illustrates the four missense mutations in the a 1 subunit of the P/Q-type, voltage-gated calcium channel on chromosome 19 causing FHM in some families, as well
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