Transcription of Pathway Analysis : An Introduction - MD Anderson Cancer …
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Pathway Analysis : An Introduction - MD Anderson Cancer …
Pathway Analysis :An IntroductionDataExperimentsStructure in Data through statisticsPathway AnalysisLiterature and other KBKnowledgeStructure in Knowledge through GO and other OntologiesGain insight into DataWhy Pathway Analysis ? Logical next step in any high- throughput experiment Treat samples Collect mRNA Label Hybridize Scan Normalize Select differentially regulated genes .. Understand the biological phenomena involved High- throughput experiments per se do not produce biological findings Genes do not work alone, but in an intricate network of interactions Helps interpret the data in the context of biological processes, pathways and networks Global perspective on the data and problem at handMicroarray ExperimentTrends in BioinformaticsSequence ComparisonTodayFunctional ComparisonTomorrowPathway DiscoveryBridgeto the Future and fully understanding of molecular ba
•High-throughput experiments per se do not produce biological findings •Genes do not work alone, but in an intricate network of ... IA, USA) at 50 or 100 μM stock concentration in H2O (see figure on left). • REH: pre-B Acute lymphoblastic leukemia cell line • MSC: Mesenchymal stroma cell line . NETWORK RELATIONSHIPS BASED ON THE ...
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