Transcription of PENICILLIN ALLERGENIC DETERMINANTS - …
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PENICILLIN ALLERGENIC DETERMINANTS ( DAP ) DESCRIPTION Main ALLERGENIC DETERMINANTS involved in type I or immediate hypersensitivity to benzylpenicillin and related antibiotics (beta-lactam), isolated, modified, and stabilised by means of lyophilisation. For exclusive use in the diagnosis of type I or immediate hypersensitivity to benzylpenicillin and related antibiotics (beta-lactam) by means of cutaneous tests (prick and intradermal tests). QUALITATIVE AND QUANTITATIVE COMPOSITION PENICILLIN ALLERGENIC DETERMINANTS are classified and labelled as: - Major Determinant Benzylpenicilloyl poly-L-lysine (PPL): formed by the bonding of the primary determinant of benzylpenicillin and related antibiotics (beta-lactam) to lysine chains. - Minor Determinant Mix (MDM): formed by Sodium benzylpenicillin, Benzylpenicilloic acid, and Sodium benzylpenicilloate, which are involved in the sensitisation to benzylpenicillin and related antibiotics (beta-lactam).
PENICILLIN ALLERGENIC DETERMINANTS ( DAP ) DESCRIPTION Main allergenic determinants involved in type I or immediate hypersensitivity …
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