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Peri-Procedure Management of Anticoagulants Page 1 of 29

Department of Clinical Effectiveness V5 Approved by the Executive Committee of the Medical Staff on 10/19/2021 Page 1 of 29 Disclaimer: This algorithm has been developed for MD Anderson using a multidisciplinary approach considering circumstances particular to MD Anderson s specific patient population, services and structure, and clinical information. This is not intended to replace the independent medical or professional judgment of physicians or other health care providers in the context of individual clinical circumstances to determine a patient's care. This algorithm should not be used to treat pregnant Management of AnticoagulantsTABLE OF CONTENTSM anagement According to Procedure 2 APPENDIX A: Procedure Bleeding 3-8 APPENDIX B: Reversal of 9-10 APPENDIX C: Management of Anticoagulant for Regional Anesthesia (neuraxial and deep peripheral nerve procedures, including lumbar puncture).

Peri-Procedure Management of Anticoagulants Department of Clinical Effectiveness V5 Approved by the Executive Committee of the Medical Staff on 10/19/2021 Note: For patients who have other risk factors for bleeding (e.g., recent bleeding event, thrombocytopenia) consider utilizing the management recommendations for high risk bleeding procedures.

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