PERSPECTIVE - ALGORISM

N engl j med 351;27 30, 2004 2787 PERSPECTIVE Human Cloning The Science and ethics of Nuclear Transplantation Rudolf Jaenisch, In addition to the moral argument against the useof somatic-cell nuclear transfer for the creation ofa child ( reproductive cloning ), there are over-whelming scientific reasons to oppose this contrast, many believe that the practice of somat-ic-cell nuclear transfer with the goal of generatingan embryonic stem-cell line (sometimes referred toas therapeutic cloning ) is justified, because itholds the promise of yielding new ways of studyingand treating a number of diseases. Once isolatedfrom a patient, an embryonic stem cell thus derivedwould be customized to the needs of the patientwho had served as the nuclear donor and thus wouldobviate the need for immunosuppressive treatmentas part of a therapeutic application. In addition, be-cause embryonic stem cells can generate most, ifnot all, types of cells in vitro, a stem cell isolatedfrom a patient with a complex genetic disease couldbe used to study the pathogenesis of the disease inculture.

n engl j med 351;27 www.nejm.org december 30, 2004 2787 PERSPECTIVE Human Cloning — The Science and Ethics of Nuclear Transplantation Rudolf Jaenisch, M.D.

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