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PFIZER REPORTS FOURTH-QUARTER AND FULL-YEAR 2021 …

PFIZER REPORTS FOURTH-QUARTER AND FULL-YEAR 2021 RESULTS. FULL-YEAR 2021 Revenues of $ Billion, Reflecting 92% Operational Growth; Excluding Contributions from Comirnaty(1) and Paxlovid, Revenues Grew 6% Operationally to $ Billion FOURTH-QUARTER 2021 Revenues of $ Billion, Reflecting 106% Operational Growth; Excluding Contributions from Comirnaty(1) and Paxlovid, Revenues Declined 2% Operationally Driven Primarily by the Impact of Fewer Selling Days Compared to the Prior- year quarter FULL-YEAR 2021 Reported Diluted EPS(2) of $ , Adjusted Diluted EPS(3) of $ ; FOURTH-QUARTER 2021. Reported Diluted EPS(2) of $ , Adjusted Diluted EPS(3) of $ Provides FULL-YEAR 2022 Record-High Guidance(4) for Revenues of $ to $ Billion and Adjusted Diluted EPS(3) of $ to $ , Reflecting 23% and 46% year -Over- year Growth at the Midpoints, Respectively Raises 2022 Revenue Guidance for Comirnaty(1) to Approximately $32 Billion, Reflecting Doses Expected to b

EPS compared to full-year 2020. QUARTERLY FINANCIAL HIGHLIGHTS (Fourth-Quarter 2021 vs. Fourth-Quarter 2020) Fourth-quarter 2021 revenues totaled $23.8 billion, an increase of $12.2 billion, or 105%, compared to the prior-year quarter, reflecting operational growth of $12.3 billion, or 106%, as well as an unfavorable impact of foreign

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