Transcription of Pharmacokinetics of Cocaine: Considerations When …
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Pharmacokinetics of Cocaine: Considerations When …
221 Pharmacokinetics of Cocaine: Considerations When AssessingCocaine Use by UrinalysisReese T. JonesINTRODUCTIONC hanges in a patient s patterns of cocaine use are generallyconsidered an important outcome measure of treatment treatment outcome measures are important as well, but if atreatment does not stop or significantly decrease the intensity of acocaine addict s cocaine use, many would question the treatment sefficacy. Examination of a patient s urine for evidence of cocaine orcocaine metabolites is an objective index of cocaine use. Like manybiochemical measures useful in medical practice, urinalysis to measurecocaine or its metabolites, although relatively simple andstraightforward from an analytic standpoint, is subject tomisinterpretation and erroneous conclusions if the underlyingbiological principles are not properly chapter considers selected aspects of cocaine clinicalpharmacology, particularly cocaine Pharmacokinetics as it applies tothe use of urinalysis to measure treatment outcome in cocaineaddiction treatment trials.
The pharmacokinetics and metabolism of cocaine make for easy monitoring of illicit cocaine use in most clinical situations. Typical patterns of use result in substantial levels of cocaine and metabolites in urine. A variety of immuno- and chromatographic assays make quantitative urine measures relatively easy compared to other drugs of abuse.
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