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Pharmacology - RS

Pharmacology -RSDone By Dana AlkhateebCorrected By Hammam MahseriClick to add textClick to add textTreatment of Bronchial Asthma Dr Munir Gharaibeh, MD, PhD, MHPED epartment of PharmacologySchool of MedicineDecember 2021 Methylxanthines Theophylline. mainstay treatment(60s-70s).withdrawn then came back .Oral ,rectal and stimulantsCardiovascular stimulants; , GIT irritation, 22 Munir Gharaibehm MD, PhD, MHPE3 Methylxanthinescame before beta 2 agonists They are tea,coffee,cacaoBecause they have low therapeutic index >> should be monitored METHYLXANTHINE DRUGSJ anuary 22 Munir Gharaibehm MD, PhD, MHPE4 METHYLXANTHINE DRUGSP redominately in CacaoPredominately in Coffee Predominately in teaXanthine nucleus Mechanism of Action of Methylxanthines Phosphodiesterase inhibition.

Corticosteroids(1950s) •Inhibit the synthesis and release of many chemical mediators (histamine, PGs and cytokines). •Suppress the inflammatory cell influx and process. •Relax bronchial smooth muscle. •Enhance beta-adrenergic responsiveness (upregulate β receptors). •Increase synthesis of adrenergic mediators. •Decrease quantity and viscosity of secretions.

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