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PhEn-602 Pharmaceutical Facility Design

J. ManfrediPhEn-602 Spring '091 PhEnPhEn--602602 Pharmaceutical Facility DesignPharmaceutical Facility DesignNotes # 8 Notes # 8J. ManfrediJ. ManfrediJ. ManfrediPhEn-602 Spring '092 Architecture & Layout ConsiderationsArchitecture & Layout ConsiderationsImportant to understand the manufacturing processes Important to understand the manufacturing processes and conduct the Facility conduct the Facility Facility layoutlayoutmust be an integrated Design that must be an integrated Design that satisfies the following:satisfies the following: Process requirementsProcess requirements Personnel flowsPersonnel flows Material flows (product, component and raw material Material flows (product, component and raw material movements) movements) Equipment layout requirementsEquipment layout requirements Operational access requirementsOperational access requirements Maintenance access requirementsMaintenance access requirementsJ.

Miscellaneous: Wall bumpers Roof hatches Armor plate on doors Shelving Storage cabinet. J. Manfredi PhEn-602 Spring '09 24 Architecture & Layout Considerations Gowning rooms play a critical role in the facility layout. Cleanroom clothing: • Designed to limit the rate of particle generation from the

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