Transcription of Plasma Cells Advanced article - Roitt
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Plasma Cells Advanced article - Roitt
Plasma CellsHeather A Minges Wols,Barat College of DePaul University, Lake Forest, Illinois, USAP lasma Cells are terminally differentiated B lymphocytes that provide protective immunitythrough the continuous secretion of antibodies. Antibody-secreting Cells develop insecondary lymphoid tissue following antigen stimulation and may enter a short-livedplasmacellpopulationthatresid eprimarilyinthenonlymphoidareaofthesplee norlymphnodes, or instead may migrate to the bone marrow where the majority enter a long-livedpopulation of Plasma humoral branch of the immune system is critical forproviding protective, circulating antibodies. In humans,antigen-specific antibody has been detected in the serumfor decades following antigen encounter.
preplasmaphenotype.However,Blimp-1isnotdetectedin memory B cells (Figure 3).Terminally differentiated plasma cells are noncycling and thus phenotypically different from their predecessors.
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