Transcription of Plasma Cells Advanced article - Roitt
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Plasma Cells Advanced article - Roitt
Plasma CellsHeather A Minges Wols,Barat College of DePaul University, Lake Forest, Illinois, USAP lasma Cells are terminally differentiated B lymphocytes that provide protective immunitythrough the continuous secretion of antibodies. Antibody-secreting Cells develop insecondary lymphoid tissue following antigen stimulation and may enter a short-livedplasmacellpopulationthatresid eprimarilyinthenonlymphoidareaofthesplee norlymphnodes, or instead may migrate to the bone marrow where the majority enter a long-livedpopulation of Plasma humoral branch of the immune system is critical forproviding protective, circulating antibodies. In humans,antigen-specific antibody has been detected in the serumfor decades following antigen encounter. The antibodypool is maintained by Plasma Cells , which secrete antibod-ies following antigen soluble antibody is necessary for providing pro-tective immunity to an individual or animal, it must be ableto circulate readily throughout the body as a means ofsurveillance.
studies highlight the differences between tissue-tropic plasma cells and suggest that antibody-secreting cells pro-ceed in maturation from secondary lymphoid tissue to
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