Transcription of Pluronic block copolymers: novel functional …
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Advanced Drug Delivery Reviews 54 (2002) 223 233. / locate / drugdeliv Pluronic block copolymers: novel functional molecules for gene therapy a, b a b Alexander V. Kabanov *, Pierre Lemieux , Sergey Vinogradov , Valery Alakhov a Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198, USA. b Supratek Pharma Inc., 531 Blvd. des Prairies, Build. 18, Laval, Quebec H7 B 1 B7, Canada Abstract Pluronic block copolymers are recognized pharmaceutical excipients listed in the US and British Pharmacopoeia. They have been used extensively in a variety of pharmaceutical formulations including delivery of low molecular mass drugs and polypeptides.
224 A.V.Kabanov et al. / Advanced Drug Delivery Reviews 54 (2002) 223–233 problems inherent to current viral-based therapies, results …
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