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Advanced Drug Delivery Reviews 54 (2002) 223 233. / locate / drugdeliv Pluronic block copolymers: novel functional molecules for gene therapy a, b a b Alexander V. Kabanov *, Pierre Lemieux , Sergey Vinogradov , Valery Alakhov a Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198, USA. b Supratek Pharma Inc., 531 Blvd. des Prairies, Build. 18, Laval, Quebec H7 B 1 B7, Canada Abstract Pluronic block copolymers are recognized pharmaceutical excipients listed in the US and British Pharmacopoeia. They have been used extensively in a variety of pharmaceutical formulations including delivery of low molecular mass drugs and polypeptides. This review describes novel applications of Pluronic block copolymers in gene therapy. In particular, these molecules can modify the biological response during gene therapy in the skeletal muscle, resulting in an enhancement of the transgene expression as well as an enhancement of the therapeutic effect of the transgene.
A.V.Kabanov et al. / Advanced Drug Delivery Reviews 54 (2002) 223–233 225 individual block copolymer molecules, termed ‘un- 4. Pluronic block copolymers as biological
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