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Polyethylene glycolgrafted polyethylenimine used to ...
Polyethylene glycol grafted polyethylenimine used to enhanceadenovirus gene deliveryKumar Singarapu, Ivy Pal, Joshua D. RamseySchool of Chemical Engineering, Oklahoma State University, Stillwater, OklahomaReceived 17 August 2012; revised 5 October 2012; accepted 9 October 2012 Published online 27 November 2012 in Wiley Online Library ( ). DOI: :An improved adenoviral-based gene delivery vectorwas developed by complexing adenovirus (Ad) with a biocom-patible, grafted copolymer PEG-g-PEI composed of polyethyl-ene glycol (PEG) and polyethylenimine (PEI). Although an Ad-based gene vector is considered relatively safe, its native tro-pism, tendency to elicit an immune response, and susceptibil-ity to inactivating antibodies makes the virus less than goal of the current study was to determine whether Adcould be complexed with a PEG-g-PEI copolymer that wouldenable the virus to transduce cells lacking the Ad receptor,while avoiding the issues commonly associat
Polyethylene glycol–grafted polyethylenimine used to enhance adenovirus gene delivery Kumar Singarapu, Ivy Pal, Joshua D. Ramsey School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma
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