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Polymorphism—A Critical Consideration in Pharmaceutical ...

Pharmaceutical F. Bauer]For more Author information, go to [Polymorphism A Critical Consideration in Pharmaceutical Development, Manufacturing, and StabilityWelcome to Pharmaceutical Solids. This column discusses scientific principles associated with Pharmaceutical solids useful to practitioners in validation and compliance. This column has been developed with the intention to help readers under-stands the principles associated with Pharmaceutical solids, and to be a useful resource for daily work applications. Enhanced process understanding is an important objective of the quality by design initiative. The key objective for this column: topic of Pharmaceutical solids is broad and com-plex. Its importance is unquestioned. Understanding the basic properties of Pharmaceutical solids is fun-damental to Pharmaceutical discovery, development, clinical studies, manufacturing, processing, problem investigations, and stability.

ciples of chemistry, physics, and mathematics. These may include thermodynamics, crystallization, analyti-cal DSC, X-Ray diffraction, and other research meth-ods. Finally, the language of pharmaceutical solids may be esoteric and intimidating. These considerations make discussion of pharma-ceutical solids a difficult task. This column addresses

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