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Power and Sample Size - Vanderbilt University

Power andSample SizeIntroductionDefinitionsRelationships CalculationsMargin ofErrorSummaryPower and Sample SizeChris Slaughter, DrPHAssistant Professor, Department of BiostatisticsVanderbilt University School of MedicineGI Research ConferenceJune 19, 2008 Power andSample SizeIntroductionDefinitionsRelationships CalculationsMargin ofErrorSummaryOutline1 Introduction2 Definitions3 Factors that Impact Power4 Sample size Calculations5 Margin of Error6 Conclusions and AdvicePower andSample SizeIntroductionDefinitionsRelationships CalculationsMargin ofErrorSummaryPower and Sample SizeFirst question asked (and the last answered)How many subjects do I need in my study?If I enroll # subjects in a treatment and control group,how likely am I to detect a significant difference betweenthe two groups?

Speci c power calculation will depend on the analysis method Continuous outcome, binary predictor Percent of time below pH 4 in a treatment and control group 2-sample t-test, Wilcoxon rank sum test Binary outcome, binary predictor ... Power and Sample Size Author: Chris Slaughter, DrPH

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