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PRACTICE PROBLEMS IN POPULATION GENETICS 1. a) Why …

PRACTICE PROBLEMS IN POPULATION GENETICS 1. In a study of the Hopi, a Native American tribe of central Arizona, Woolf and Dukepoo (1959) found 26 albino individuals in a total POPULATION of 6000. This form of albinism is controlled by a single gene with two alleles: albinism is recessive to normal skin coloration. a) Why can t you calculate the allele frequencies from this information alone? Because you can t tell who might be a carrier just by looking. b) Calculate the expected allele frequencies and genotype frequencies if the POPULATION were in Hardy-Weinberg equilibrium. How many of the Hopi are estimated to be carriers of the recessive albino allele? If we assume that the POPULATION s in H-W equilibrium, then the frequency of individuals with the albino genotype is the square of the frequency of the albino allele. In other words, freq (aa) = q2. Freq (aa) = 26/6000 = , and the square root of that is , which is q, the frequency of the albino allele.

Predicted frequency of homozygous greys = 0.376 * 0.376 = 0.141 Predicted frequency of heterozygous greys = 2 * 0.376 * 0.624 = 0.469 Frequency of homozygous yellows = 0.389. CHECK: These add up to 1 (well, to 0.999, but that’s round-off error) If yellow is …

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