Transcription of Pre-eclampsia: pathophysiology and clinical implications
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Pre-eclampsia: pathophysiology and clinical implications
Interactions between senescence of the placenta and a maternal genetic predisposition to cardiovascular and metabolic disease. While often presented as distinct sub-types, in reality the balance between the placental and maternal causations most likely varies among indi-viduals across the spectrum of gestational age at clinical presentation. We discuss the pathophysiology in the light of recent advances of our understanding of the maternal-fetal interactions that take place in the first weeks fol-lowing implantation, and emphasize the importance of the endometrium during the pre- and peri-conceptional periods for pregnancy and selection criteriaA PubMed search (pre- eclampsia OR preeclampsia) AND (placenta OR placental)] at the end of 2018 with no date restrictions yielded 10 611 citations.
3Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK 4Magee-Womens Research Institute, Depts. Obstetric Gynecology and Reproductive Sciences, Epidemiology, and Clinical and Translational Research, University of Pittsburgh, USA 5Dept of Pathology, University of Cambridge, UK. Correspondence to: A Moffett am485@cam.ac.uk
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